"Mitochondrial DNA has for a long time been implicated in the ageing process. The idea was first proposed by Harman, who predicted the involvement of free radicals in the ageing process (80,81). The concept was that the close proximity between the sites of ROS production and the mtDNA would render the latter more susceptible to damage than the nuclear genome, and lead to defects in mitochondrial metabolism."
qualcuno mi saprebbe dire come si potrebbe rendere in italiano quel "close proximity"?